THE USEFULNESS OF MESENCHYMAL STEM CELLS
In response to publication in Serbia about the importance and the usefulness of mesenchymal stem cells, Biohellenika informs the parents about the current applications of this type of stem cells.
1. There are 329 approved by FDA, USA clinical trials concerning the use of mesenchymal stem cells. www.clinicaltrials.gov
2. Sources of mesenchymal stem cells are: umbilical cord tissue (Wharton’s Jelly)-deciduous tooth pulp, wisdom tooth pulp, adipose tissue.
3. Mesenchymal stem cells currently are used in:
Treatment of autoimmune diseases, like multiple sclerosis (1, 2), inflammatory bowel diseases (3, 4), rheumatoid arthritis (5), diabetes type I (6,7), idiopathic lung fibrosis (8), Graft Versus Host Disease (9).
Heart infarct (10) and ischemic myocardiopathy (11)
Stroke (12, 13)
Cerebral palsy (14, 15)
Acute renal failure (16)
Liver failure (17)
Burns (18)
Fractures (19)
diabetic foot (20,21)
Osteoarthritis (22)
Skin aging (23)
Gene therapy (24)
1. Arch Med Res. 2013 May;44(4):266-72. Evaluation of Cytokines in Multiple Sclerosis Patients Treated with Mesenchymal Stem Cells. Mohyeddin Bonab M, Mohajeri M, Sahraian MA, Yazdanifar M, Aghsaie A, Farazmand A, Nikbin B. Curr Stem Cell Res Ther. 2012 Nov;7(6):407-14.
2. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study.Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Lancet Neurol. 2012 Feb;11(2):150-6.
3. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohns disease: results of a phase I study. Duijvestein M, Vos AC, Roelofs H, Wildenberg ME, Wendrich BB, Verspaget HW, Kooy-Winkelaar EM, Koning F, Zwaginga JJ, Fidder HH, Verhaar AP, Fibbe WE, van den Brink GR, Hommes DW. Gut. 2010 Dec;59(12):1662-9.
4. Mayo Clin Proc. 2012 Sep;87(9):909-14. Mesenchymal stromal cell infusions as rescue therapy for corticosteroid-refractory adult autoimmune enteropathy. Ciccocioppo R, Russo ML, Bernardo ME, Biagi F, Catenacci L, Avanzini MA, Alvisi C, Vanoli A, Manca R, Luinetti O, Locatelli F, Corazza GR.
5. Pediatr Res. 2012 Apr;71(4 Pt 2):433-8. 22.Application of autologous stem cell transplantation in various adult and pediatric rheumatic diseases. Tyndall A
6. Endocr J. 2013;60(3):347-57. Long term effects of the implantation of Whartons jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y.
7. PLoS One. 2012;7(5):e38189. Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines. Yeung TY, Seeberger KL, Kin T, Adesida A, Jomha N, Shapiro AM, Korbutt GS.
8. Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal. Tzouvelekis A, Koliakos G, Ntolios P, Baira I, Bouros E, Oikonomou A, Zissimopoulos A, Kolios G, Kakagia D, Paspaliaris V, Kotsianidis I, Froudarakis M, Bouros D. J Transl Med. 2011 Oct 21;9:182.
9. Best Pract Res Clin Haematol. 2011 Mar;24(1):65-72. Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages. Ringden O, Le Blanc K.
10. Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina. Friis T, Haack-Sørensen M, Mathiasen AB, Ripa RS, Kristoffersen US, Jørgensen E, Hansen L, Bindslev L, Kjær A, Hesse B, Dickmeiss E, Kastrup J. Scand Cardiovasc J. 2011 Jun;45(3):161-8.
11. Stem cells transplantation combined with long-term mechanical circulatory support enhances myocardial viability in end-stage ischemic cardiomyopathy. Anastasiadis K, Antonitsis P, Doumas A, Koliakos G, Argiriadou H, Vaitsopoulou C, Tossios P, Papakonstantinou C, Westaby S. Int J Cardiol. 2012 Mar 22;155(3):e51-3.
12. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, Waxman SG, Kocsis JD. Brain. 2011 Jun;134(Pt 6):1790-807.
13. Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Ikegame Y, Yamashita K, Hayashi Si et al. Cytotherapy. 2011 Jan 13.
14. Case Reports in TransplantationVolume 2013, Article ID 951827, 6 pagesCase Report
First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood
A. Jensen1 and E. Hamelmann2
15. Stem Cells. 2013 Mar;31(3):581-91. doi: 10.1002/stem.1304. Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial. Min K, Song J, Kang JY, Ko J, Ryu JS, Kang MS, Jang SJ, Kim SH, Oh D, Kim MK, Kim SS, Kim M.
16. Am J Nephrol. 2012;35(6):531-9. Use of mesenchymal stem cells and darbepoetin improve ischemia-induced acute kidney injury outcomes. Altun B, Yilmaz R, Aki T, Akoglu H, Zeybek D, Piskinpasa S, Uckan D, Purali N, Korkusuz P, Turgan C.
17. Stem Cells Transl Med. 2012 Oct;1(10):725-31. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Shi M, Zhang Z, Xu R, Lin H, Fu J, Zou Z, Zhang A, Shi J, Chen L, Lv S, He W, Geng H, Jin L, Liu Z, Wang FS.
18. Plast Reconstr Surg. 2007 Apr 15;119(5):1409-22; discussion 1423-4. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Rigotti G, Marchi A, Galiè M, Baroni G, Benati D, Krampera M, Pasini A, Sbarbati A.
19. Mol Ther. 2013 Jun 4. doi: 10.1038/mt.2013.109. Stem Cell-based Therapy for Prevention of Delayed Fracture Union: A Randomized and Prospective Preliminary Study. Liebergall M, Schroeder J, Mosheiff R, Gazit Z, Yoram Z, Rasooly L, Daskal A, Khoury A, Weil Y, Beyth S.
20. Circ J. 2012;76(7):1750-60..Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. Lee HC, An SG, Lee HW, Park JS, Cha KS, Hong TJ, Park JH, Lee SY, Kim SP, Kim YD, Chung SW, Bae YC, Shin YB, Kim JI, Jung JS.
21. Diabetes Res Clin Pract. 2011 Apr;92(1):26-36. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Lu D, Chen B, Liang Z, Deng W, Jiang Y, Li S, Xu J, Wu Q, Zhang Z, Xie B, Chen S.
22. Articular cartilage repair with autologous bone marrow mesenchymal cells.
Matsumoto T, Okabe T, Ikawa T, Iida T, Yasuda H, Nakamura H, Wakitani S. J Cell Physiol. 2010 Nov;225(2):291-5.
23. Adipose-derived stem cells as a new therapeutic modality for ageing skin. Kim JH, Jung M, Kim HS, Kim YM, Choi EH. Exp Dermatol. 2011 May;20(5):383-7.
24. Gene Therapy of Multiple Sclerosis Using Interferon β -Secreting Human Bone Marrow Mesenchymal Stem Cells. Ryu CH, Park KY, Hou Y, Jeong CH, Kim SM, Jeun SS. Biomed Res Int. 2013;2013:696738.
This is a very small part of the international literature that is referred to current clinical applications of mesenchymal stem cells in patients.